Gout, a form of arthritis, is extremely painful and associated with an increased risk for cardiovascular problems. But there is a bright side: It may be linked to a reduced risk for Alzheimers disease.
Researchers compared 59,204 British men and women with gout to 238,805 without the ailment, with an average age of 65. Patients were matched for sex, B.M.I., smoking, alcohol consumption and other characteristics. The study, in The Annals of the Rheumatic Diseases, followed the patients for five years.
研究人员花了五年时间对英国的59204名痛风患者和238805名非痛风患者进行比较。他们的平均年龄为65岁，在性行为、体重指数、吸烟、喝酒等方面都比较接近。这项研究发表在《风湿病疾病纪事》(The Annals of the Rheumatic Diseases)上。
They found 309 cases of Alzheimers among those with gout and 1,942 among those without. Those with gout, whether they were being treated for the condition or not, had a 24 percent lower risk of Alzheimers disease.
The reason for the connection is unclear. But gout is caused by excessive levels of uric acid in the blood, and previous studies have suggested that uric acid protects against oxidative stress. This may play a role in limiting neuron degeneration.
This is a dilemma, because uric acid is thought to be bad, associated with heart disease and stroke, said the senior author, Dr. Hyon K. Choi, a professor of medicine at Harvard. This is the first piece of data suggesting that uric acid isnt all bad. Maybe there is some benefit. It has to be confirmed in randomized trials, but thats the interesting twist in this story.